CMLD010509|CMLD 010509;SDS-1-021

Cas No.:	256497-58-2
Chemical Name:	(1R,2R,3S,3aR,8bS)-3a-(4-bromophenyl)-1,8b-dihydroxy-N,6,8-trimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide
Synonyms:	CMLD 010509;SDS-1-021
SMILES:	O1C2=CC(OC)=CC(OC)=C2[C@](O)2[C@@H](O)[C@@H](C(NOC)=O)[C@H](C3=CC=CC=C3)[C@@]12C1=CC=C(Br)C=C1
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A rocaglate (flavagline) derivative that acts a highly specific inhibitor of the oncogenic translation program supporting MM, including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1; induces apoptosis and inhibits the heat shock response in MM cells (IC50=10 nM), a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism and is highly effective in vivo in several mouse models.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47701	c-Myc inhibitor 4	c-Myc inhibitor 4 is a potent, orally bioavailable c-MYC-reducing compound.
DC45837	MYC-IN-2	MYC-IN-2 is a MYC protein-protein inhibitor. MYC-IN-2 can be used for the research of cancer.
DC45348	NY2267	NY2267 is a disruptor of Myc-Max interaction, with an IC50 of 36.5 μM.
DC40285	Lusianthridin	Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling.
DC11684	sAJM-589	sAJM-589 is a novel, potent small molecule Myc inhibitor that disrupts the Myc-Max leucine-zipper heterodimer with IC50 of 1.8 uM.
DC11918	CMLD010509	A rocaglate (flavagline) derivative that acts a highly specific inhibitor of the oncogenic translation program supporting MM, including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1.