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RU-301

  Cat. No.:  DC11689   Featured
Chemical Structure
1110873-99-8
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Field of application
RU-301 (RU301) is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1110873-99-8
Chemical Name: 2-(((3-methylisoxazol-5-yl)methyl)thio)-N-(2-((2-nitro-4-(trifluoromethyl)phenyl)amino)ethyl)benzamide
Synonyms: RU 301;RU301
SMILES: C(NCCNC1=CC=C(C(F)(F)F)C=C1[N+]([O-])=O)(=O)C1=CC=CC=C1SCC1ON=C(C)C=1
Formula: C21H19F3N4O4S
M.Wt: 480.462
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Description: RU-301 is a pan-TAM receptor inhibitor, exerts pan-TAM inhibitory activity by binding at the interface between Gas6 and the Ig1 domain of the respective TAMs with Kd and IC50 values of 12 μM and 10 μM, respectively[1].
Target: IC50: 10 μM (TAM)[1]
References: [1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC11689 RU-301 RU-301 (RU301) is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.
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