BMS-816336|BMS 816336;BMS816336

Cas No.:	1009583-20-3
Chemical Name:	2-((1R,2R,3S,5R,6R)-6-hydroxy-2-phenyladamantan-2-yl)-1-(3-hydroxyazetidin-1-yl)ethan-1-one
Synonyms:	BMS 816336;BMS816336
SMILES:	C(N1CC(O)C1)(=O)C[C@](C1=CC=CC=C1)1[C@@]([H])2CC3C[C@H]1C[C@@]([H])([C@H]3O)C2
Formula:	C₂₁H₂₇NO₃
M.Wt:	341.451
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM; displays >10,000-fold selectivity over huma 11β-HSD2; exhibits a robust acute pharmacodynamic effect in cynomolgus monkeys (ED50=0.12 mg/kg) and in DIO mice.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC11761	BMS-816336	A novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM.
DC11842	BI 135585	BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively.