BI 135585
Cat. No.: DC11842
Chemical Structure
1114561-85-1
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Field of application
BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively.
| Cas No.: |
1114561-85-1 |
| Chemical Name: |
(S)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one |
| Synonyms: |
BI-135585;BI135585 |
| SMILES: |
O1[C@](CC(O)(C)C)(C2=CC=CC=C2)CCN([C@@H](C2=CC=C(C3C=CN(C)C(=O)C=3)C=C2)C)C1=O |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively; exhibits >1,000-fold selectivity over other hydroxysteroid dehydrogenases; inhibits 11β HSD1 activity in adipose tissue, displays desirable pharmacodynamic properties in vivo. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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