Cas No.: | |
Chemical Name: | 2-acetamido-5-chloro-N-(4-(2,5-dichlorobenzamido)phenyl)benzamide |
SMILES: | C(NC1=CC=C(NC(=O)C2=CC(Cl)=CC=C2Cl)C=C1)(=O)C1=CC(Cl)=CC=C1NC(=O)C |
Formula: | C22H16Cl3N3O3 |
M.Wt: | 476.738 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A novel cell permeable smoothened antagonist with IC50 of 3.1 nM in Hh-dependent Gli transcriptional activity assay; blocked Gli2 accumulation at the ciliary tip in response to SAG treatment, also blocks SAG-induced Gpr161 ciliary depletion. |