Cas No.: | 548779-60-8 |
Chemical Name: | N,N'-(1,4-phenylene)bis(2,5-dichlorobenzamide) |
Synonyms: | IHR 1;IHR1 |
SMILES: | C(NC(=O)C1=CC(Cl)=CC=C1Cl)1=CC=C(NC(=O)C2=CC(Cl)=CC=C2Cl)C=C1 |
Formula: | C20H12Cl4N2O2 |
M.Wt: | 454.13 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay; blocks Smo accumulation in the primary cilium without inhibiting SAG-induced pathway response. |