IHR-1

  Cat. No.:  DC11785  
Chemical Structure
548779-60-8
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More than 5000 active chemicals with high quality for research!
Field of application
A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay.
Cas No.: 548779-60-8
Chemical Name: N,N'-(1,4-phenylene)bis(2,5-dichlorobenzamide)
Synonyms: IHR 1;IHR1
SMILES: C(NC(=O)C1=CC(Cl)=CC=C1Cl)1=CC=C(NC(=O)C2=CC(Cl)=CC=C2Cl)C=C1
Formula: C20H12Cl4N2O2
M.Wt: 454.13
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay; blocks Smo accumulation in the primary cilium without inhibiting SAG-induced pathway response.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC47157 KAAD-Cyclopamine KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist.
DC40460 IHR-Cy3 IHR-Cy3 is a potent fluorescent Smo antagonist with an IC50?of 100 nM.
DC12288 MRT-83 MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range.
DC11784 IHR-Nac A novel cell permeable smoothened antagonist with IC50 of 3.1 nM in Hh-dependent Gli transcriptional activity assay.
DC11785 IHR-1 A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay.
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