IDX899|IDX-899;IDX 899;Fosdevirine;GSK 2248761

Cas No.:	1018450-26-4
Chemical Name:	5-chloro-3-[[3-[(E)-2-cyanovinyl]-5-methyl-phenyl]-(R)-methoxy-phosphoryl]-1H-indole-2-carboxamide
Synonyms:	IDX-899;IDX 899;Fosdevirine
SMILES:	N1C2=C(C=C(Cl)C=C2)C([P@](C2=CC(C)=CC(/C=C/C#N)=C2)(OC)=O)=C1C(N)=O
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A novel potent, selective HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) with EC50 of 1, 1.3, 2.8 and 11 nM for WT, K103N, Y181C and K103N/Y181C, respectively; shows substantial benefits in term of HIV mutant activities, physicochemical properties and pharmacological profile.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC9864	Azidothymidine (AZT)	Selective reverse transcriptase inhibitor. Exhibits 100-fold selectivity for HIV reverse transcriptase over DNA polymerase α.
DC9479	Raltegravir (potassium salt)	Raltegravir potassium salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
DC9477	NBD-557	NBD-557 is a potentially HIV-1 inhibitor.
DC4234	Etravirine	Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1).
DC8897	Delavirdine	Delavirdine(U 90152) is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI).
DC11352	Delavirdine (mesylate)	Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively).
DC9480	Atazanavir (sulfate)	Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor.
DC11854	IDX899	A novel potent, selective HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) with EC50 of 1, 1.3, 2.8 and 11 nM for WT, K103N, Y181C and K103N/Y181C, respectively.