Delavirdine (mesylate)|cas 147221-93-0

Cas No.:	147221-93-0
Synonyms:	Delavirdine (mesylate)；U 90152
SMILES:	CC(C)NC1=CC=CN=C1N2CCN(C(C3=CC4=C(C=CC(NS(C)(=O)=O)=C4)N3)=O)CC2.O=S(O)(C)=O
Formula:	C₂₂H₂₈N₆O₃S^.CH₃SO₃H
M.Wt:	552.7
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively).It inhibits growth of clinical isolates of HIV-1 (ED50s = <0.005-0.69 μM). Delavirdine blocks replication of 25 primary HIV-1 isolates, including strains resistant to 3'-azido-2',3'-deoxythymidine (AZT) or 2',3'-dideoxyinosine, with a mean ED50 value of 0.066 μM. Delavirdine also inhibits growth of L. infantum promastigotes (IC50 = 26.1 μM).Formulations containing delavirdine have been used in the treatment of HIV.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC9864	Azidothymidine (AZT)	Selective reverse transcriptase inhibitor. Exhibits 100-fold selectivity for HIV reverse transcriptase over DNA polymerase α.
DC9479	Raltegravir (potassium salt)	Raltegravir potassium salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
DC9477	NBD-557	NBD-557 is a potentially HIV-1 inhibitor.
DC4234	Etravirine	Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1).
DC8897	Delavirdine	Delavirdine(U 90152) is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI).
DC11352	Delavirdine (mesylate)	Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively).
DC9480	Atazanavir (sulfate)	Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor.
DC7058	Amprenavir	Amprenavir (Agenerase) is a HIV protease inhibitor(Ki=0.6 nM) used to treat HIV infection.
DC11854	IDX899	A novel potent, selective HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) with EC50 of 1, 1.3, 2.8 and 11 nM for WT, K103N, Y181C and K103N/Y181C, respectively.