Cas No.: | 1161921-82-9 |
Chemical Name: | (S)-4-(4-cyano-2-(methylsulfonyl)phenyl)-3,6-dimethyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carbonitrile |
Synonyms: | BAY 85-8501;BAY 858501 |
SMILES: | C(=O)1N(C2=CC=CC(C(F)(F)F)=C2)C(C)=C(C#N)[C@H](C2=CC=C(C#N)C=C2S(C)(=O)=O)N1C |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | BAY 85-8501 (BAY85-8501) is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 65 pM; displays no significant inhibition toward 21 related serine proteases (>30 uM); demonstrates completely prevented the development of lung injury and subsequent inflammation in vivo. |