BAY85-8501

  Cat. No.:  DC11859  
Chemical Structure
1161921-82-9
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More than 5000 active chemicals with high quality for research!
Field of application
BAY 85-8501 (BAY85-8501) is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 65 pM.
Cas No.: 1161921-82-9
Chemical Name: (S)-4-(4-cyano-2-(methylsulfonyl)phenyl)-3,6-dimethyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
Synonyms: BAY 85-8501;BAY 858501
SMILES: C(=O)1N(C2=CC=CC(C(F)(F)F)=C2)C(C)=C(C#N)[C@H](C2=CC=C(C#N)C=C2S(C)(=O)=O)N1C
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: BAY 85-8501 (BAY85-8501) is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 65 pM; displays no significant inhibition toward 21 related serine proteases (>30 uM); demonstrates completely prevented the development of lung injury and subsequent inflammation in vivo.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC11859 BAY85-8501 BAY 85-8501 (BAY85-8501) is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 65 pM.
DC11868 Freselestat A potent, selective and orally active human neutrophil elastase (HNE) inhibitor with Ki of 12 nM.
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