Freselestat

  Cat. No.:  DC11868  
Chemical Structure
208848-19-5
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, selective and orally active human neutrophil elastase (HNE) inhibitor with Ki of 12 nM.
Cas No.: 208848-19-5
Chemical Name: 2-(5-amino-6-oxo-2-phenylpyrimidin-1(6H)-yl)-N-(1-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl)acetamide
Synonyms: ONO-6818;ONO 6818
SMILES: O=C(NC(C(C1=NN=C(C(C)(C)C)O1)=O)C(C)C)CN(C(C2=CC=CC=C2)=NC=C3N)C3=O
Formula: C23H28N6O4
M.Wt: 452.51
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent, selective and orally active human neutrophil elastase (HNE) inhibitor with Ki of 12 nM; dispalys >100-fold selectivity over a panel of related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase; attenuates HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count, inhibits acute lung injury induced by HNE in rats.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC11859 BAY85-8501 BAY 85-8501 (BAY85-8501) is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 65 pM.
DC11868 Freselestat A potent, selective and orally active human neutrophil elastase (HNE) inhibitor with Ki of 12 nM.
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