| Cas No.: | 208848-19-5 |
| Chemical Name: | 2-(5-amino-6-oxo-2-phenylpyrimidin-1(6H)-yl)-N-(1-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl)acetamide |
| Synonyms: | ONO-6818;ONO 6818 |
| SMILES: | O=C(NC(C(C1=NN=C(C(C)(C)C)O1)=O)C(C)C)CN(C(C2=CC=CC=C2)=NC=C3N)C3=O |
| Formula: | C23H28N6O4 |
| M.Wt: | 452.51 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A potent, selective and orally active human neutrophil elastase (HNE) inhibitor with Ki of 12 nM; dispalys >100-fold selectivity over a panel of related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase; attenuates HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count, inhibits acute lung injury induced by HNE in rats. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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