AZD 3147 |CAS 1101810-02-9|DC Chemicals

Cas No.:	1101810-02-9
Chemical Name:	AZD3147
Synonyms:	AZD3147;AZD 3147;(S)-1-(4-(4-(1-(cyclopropylsulfonyl)cyclopropyl)-6-(3-methylmorpholino)pyrimidin-2-yl)phenyl)-3-(2-hydroxyethyl)thiourea;BCP24240;BDBM50072961;NSC784815;SB18923;1-(2-Hydroxyethyl)-3-[4-[4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methylmorpholino]-2-pyrimidinyl]phenyl]thiourea;1-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2
SMILES:	S(C1CC1)(C1(C2C=C(N=C(C3C=CC(=CC=3)NC(NCCO)=S)N=2)N2CCOC[C@@H]2C)CC1)(=O)=O
Formula:	C₂₄H₃₁N₅O₄S₂
M.Wt:	517.664042711258
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective dual mTORC1 and mTORC2 inhibitor with enzyme IC50 of 1.5 nM; weakly inhibits PI3K isoforms with IC50 of 1-10 uM, potently inhibits pAKT at Ser473 with pIC50 of 8.25; has exellentphysicochemical and pharmacokinetic properties.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47561	MHY-1685	MHY-1685, a novel mammalian target of rapamycin (mTOR) inhibitor, provides opportunities to improve hCSC-based myocardial regeneration.
DC11816	RapaLink-1	RapaLink-1 is a third-generation mTOR inhibitor that overcomes resistance to existing first- and second-generation inhibitors; blocks mTOR signaling of the F2108L mTOR and M2327I mTOR drug resistant mutants; RapaLink-1 is more potent mTOR inhibitor than rapamycin.
DC1006	OSI-027	OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively.
DC7210	LY-303511(Nv-128)	LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K.
DC7171	INK-128(Sapanisertib)	INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM; >200-fold less potent to class I PI3K isoforms.
DC11866	AZD 3147	A potent, selective dual mTORC1 and mTORC2 inhibitor with enzyme IC50 of 1.5 nM.