EDD3|EDD 3

Cas No.:	25279-15-6
Chemical Name:	(8R,10R,12R,14R,17S)-12-hydroxy-17-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one
Synonyms:	EDD 3
SMILES:	C1[C@@](C)2C(CC[C@](C)3C2C[C@H](O)C2[C@]3(C)CC[C@H]2[C@](C)2CC[C@@H](C(O)(C)C)O2)C(C)(C)C(=O)C1
Formula:	C₃₀H₅₀O₄
M.Wt:	474.715610027313
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A novel Notch inhibitor that reduces protein expression of NOTCH1, NICD and HES1 in HEK293 cells and downregulates Notch target genes; inhibits proliferation and induces G0/G1 cell cycle arrest of ORL-150 cells through inducing p27KIP1.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC46594	SAHM1 TFA	SAHM1 TFA is a Notch pathway inhibitor. SAHM1 TFA stabilizes hydrocarbon-stapled alpha helical peptide. SAHM1 TFA targets the protein-protein interface and prevents Notch complex assembly.
DC46314	Notch 1 TFA	Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types.
DC41036	RBPJ Inhibitor-1	RBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation.
DC11930	EDD3	A novel Notch inhibitor that reduces protein expression of NOTCH1, NICD and HES1 in HEK293 cells and downregulates Notch target genes.
DC11489	6-alkynyl Fucose	A fucose analog that inhibits Dll-induced Notch signaling by reducing Notch ligand Dll1-Notch1 binding, but not Jag1.