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CCG 258748

  Cat. No.:  DC11956  
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 8 nM.
Cas No.:
Chemical Name: 5-((3S,4R)-3-(((1H-indazol-5-yl)oxy)methyl)piperidin-4-yl)-N-((1H-pyrazol-5-yl)methyl)-2-fluorobenzamide
Synonyms: CCG258748;CCG-258748
SMILES: C(NCC1NN=CC=1)(=O)C1=CC([C@H]2CCNC[C@@H]2COC2C=CC3=C(C=2)C=NN3)=CC=C1F
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent, selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 8 nM; displays 30-fold selectivity over GRK5, and no significant inhibitory activity against GRK1, PKA and ROCK1.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC11956 CCG 258748 A potent, selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 8 nM.
DC11957 CCG 224061 A potent, relatively selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 66 nM.
DC11958 CCG 258001 A potent, relatively selective G protein-coupled receptor kinase GRK2 inhibitor with IC50 of 280 nM.
DC11765 GRK2-IN-115h hydrochloride A highly potent and selective GRK2 inhibitor with IC50 of 18 nM.
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