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Pyrrolidinedithiocarbamate ammonium;APDC, PDTC

  Cat. No.:  DC20178   Featured
Chemical Structure
5108-96-3
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More than 5000 active chemicals with high quality for research!
Field of application
Ammonium pyrrolidine dithiocarbamate (PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 5108-96-3
Chemical Name: Pyrrolidine dithiocarbamic acid
Synonyms: 1-Pyrrolidinecarbodithioic acid, ammoniumsalt;Ammonium pyrrolidinedithiocarbamate~APDC;APDC;APDTC;Pyrrolidinedithiocarbamate;ammonium pyrrolidine-1-carbodithioate;Ammonium tetramethylenedithiocarbamate;PYRROLIDINE-N-DITHIOCARBAMIC ACID AMMONIUM SALT;PYRROLIDINECARBODITHIOIC ACID AMMONIUM SALT;PYRROLIDINEDITHIOCARBAMATE AMMONIUM;PYRROLIDINEDITHIOCARBAMATE, AMMONIUM DERIVATIVE;PYRROLIDINEDITHIOCARBAMATE AMMONIUM SALT;PYRROLIDINEDITHIOCARBAMIC ACID AMMONIUM SALT;PYRROLIDINE-1-DITHIOCARBOXYLIC ACID AMMONIUM SALT;Ammonium pyrrolidinedithiocarbamate;Ammonium 1-Pyrrolidinecarbodithioate [Reagent for Atomic Absorption Analysis];Ammonium 1-pyrrolidinedithiocarbamate;PDTC (PDC, APDC, Pyrrolidinedithiocarbamate Ammonium);Pyrrolidinedithiocarbamate (ammonium);1-PYRROLIDINECARBODITHIOIC ACID;1-Pyrrolidinecarbodithioic acid ammonium salt,APDC,Ammonium pyrrolidinecarbodithioate;1-Pyrrolidinedithiocarboxylic acid ammonium salt;Ammonium 1-Pyrrolidinecarbodithioate;Ammonium pyrrolidine;Ammonium Pyrrolidine-N-dithiocarbamate;Ammoniumpyrrolidinedithiocarb;APCD;APDC AMMONIUM SALT;APDTC AMMONIUM SALT;PDC;PDTC;Pyrrolindinedithiocarbamate ammonium;1-Pyrrolidinecarbodithioic Acid Ammonium Salt;Pyrrolidine dithiocarbamate;Pyrrolidine-1-carbodithioic acid;Pyrrolidine dithiocarbamic acid;Tetramethylenedithiocarbamic acid;Pyrrolidine-N-carbodithioic acid;Ammonium pyrrolidine dithiocarbamate;1-Pyrrolidinecarbodithioic acid, ammonium salt;C5H9NS2;NSC298194;ammonium tetramethylene dithiocarbamate;NCIOpen2_00
SMILES: S([H])C(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=S
Formula: C5H9NS2
M.Wt: 147.2617
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Pyrrolidinedithiocarbamate ammonium is a selective NF-κB inhibitor.
In Vivo: The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis[2].
In Vitro: Pretreatment of cells with pyrrolidinedithiocarbamate (3-1000 μM) dose-dependently attenuate IL-8 production. Furthermore, pyrrolidinedithiocarbamate (100 μM) suppresses the accumulation of IL-8 mRNA. Pyrrolidinedithiocarbamate inhibits the activation of NF-κB, because pyrrolidinedithiocarbamate suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate decrease IL-8 production by intestinal epithelial cells[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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