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SZL P1-41

  Cat. No.:  DC23210   Featured
Chemical Structure
222716-34-9
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More than 5000 active chemicals with high quality for research!
Field of application
A small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 222716-34-9
Chemical Name: 4H-1-Benzopyran-4-one, 3-(2-benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-
SMILES: O=C1C2C(=C(C(=C(C=2)CC)O)CN2CCCCC2)OC=C1C1SC2C(=CC=CC=2)N=1
Formula: C24H24N2O3S
M.Wt: 420.524
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Chan CH et al. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 1;154(3):556-68. [2]. Chan CH, et al. Skp2: a dream target in the coming age of cancer therapy. Cell Cy
Description: SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes.
In Vivo: SZL P1-41 exhibits potent anti-tumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival.
In Vitro: SZL P1-41 also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as well as triggering p53-independent cellular senescence. SZL P1-41 prevent Skp2-Skp1 interactions and Skp2 SCF E3 ligase activity. The reference concentration is 5 uM. SZL P1-41 restricts cancer cell survival through triggering p53-independent cellular senescence and inhibiting aerobic glycolysis.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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