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IU1

  Cat. No.:  DC26005   Featured
Chemical Structure
314245-33-5
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More than 5000 active chemicals with high quality for research!
Field of application
IU1 is a selective USP14 inhibitor. IU1 prevents ventilator-induced lung injury in rats.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 314245-33-5
Chemical Name: IU1
Synonyms: IU1;Vismodegib (GDC-0449);1-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone;1-[1-(4-FLUOROPHENYL)-2,5-DIMETHYL-1H-PYRROL-3-YL]-2-(1-PYRROLIDINYL)ETHANONE;AC1LDUCV;AC1Q2HNB;CHEMBL1410015;F1142-1244;SureCN6923146;Usp14 inhibitor;1-[1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-pyrrolidin-1-yl-ethanone
SMILES: CC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3
Formula: IU
M.Wt: 364.933
Purity: >98%
Description: IU1 is a special Usp14 inhibitor with IC50 of 4-5 μM.
Target: IC50: 4-5 μM (Usp14)[1]
In Vitro: Usp14, a proteasome-associated deubiquitinating enzyme, can inhibit the degradation of ubiquitin-protein conjugates, in vivo and in vitro. IU1inhibits the catalytic activity of proteasome associated Usp14 in vitro. The IC50 of IU1 for Usp14 is 4-5 μM. IU1 binds specifically to the activated form of Usp14. IU1 can potentially inhibit Usp14 by preventing its docking on the proteasome, but direct tests of this scenario proved negative. Usp14 inhibition is rapidly established upon addition of IU1 and rapidly reversed upon its removal. IU1 also promotes degradation of Sic1, a CDK inhibitor from S. cerevisiae[1].
References: [1]. Lee BH, et al. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature. 2010 Sep 9;467(7312):179-84.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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