LXS-196

  Cat. No.:  DC26012   Featured
Chemical Structure
1874276-76-2
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More than 5000 active chemicals with high quality for research!
Field of application
LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma.
Cas No.: 1874276-76-2
Chemical Name: LXS196
Synonyms: LXS196
SMILES: NC1=C(C(NC2=C(N3CCC(C)(N)CC3)C=CC=N2)=O)N=C(C4=NC=CC=C4C(F)(F)F)C=N1
Purity: >98%
Description: LXS196 is a potent and orally active protein kinase C (PKC) inhibitor under Phase I clinical trials for the treatment of uveal melanoma.
In Vitro: Upon oral administration, protein kinase C inhibitor LXS196 binds to and inhibits PKC, which prevents the activation of PKC-mediated signaling pathways. This may lead to the induction of cell cycle arrest and apoptosis in susceptible tumor cells. PKC, a serine/threonine protein kinase overexpressed in certain types of cancer cells, is involved in tumor cell differentiation, proliferation, invasion and survival[1].
References: [1]. Protein Kinase C Inhibitor LXS196
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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