Cyclo(L-Pro-L-Val)

  Cat. No.:  DC26050   Featured
Chemical Structure
2854-40-2
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Field of application
Cyclo(L-Pro-L-Val) is a diketopiperazine that has been found in the marine sponge T. ignis, the bacterium B. pumilus, and the fungus A. fumigatus, among others.
Cas No.: 2854-40-2
Chemical Name: Pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro-3-(1-methylethyl)-, (3S,8aS)-
Synonyms: Pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro-3-(1-methylethyl)-, (3S,8aS)-;(3S,8aS)-3-propan-2-yl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;Cyclo(-Pro-Val);(3S,8aS)-3-Isopropylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione;cyclo(-L-pro-L-val-);cyclo-(L-Val-L-Pro)
SMILES: CC([C@H]1C(N2CCC[C@H]2C(N1)=O)=O)C
Formula: C10N2O2H16
M.Wt: 196.2462
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Cyclo(L-Pro-L-Val) is a diketopiperazine that has been found in the marine sponge T. ignis, the bacterium B. pumilus, and the fungus A. fumigatus, among others.It is active against the bacteria S. aureus and B. subtilis (MICs = 16.3 and 18.2 µg/ml, respectively) but not E. coli (MIC = >20 µg/ml).Cyclo(L-Pro-L-Val) inhibits activation of a LuxR-dependent E. coli biosensor by the quorum-sensing molecule 3-oxo-hexanoyl-homoserine lactone (IC50 = 0.4 mM) and activates violacein pigment production in the LuxR-dependent C. violaceum acyl homoserine lactone reporter strain CV026.However, it does not activate or inhibit lacZ-based reporter fusions in S. liquefaciens or A. tumefaciens.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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