MC-Ala-Ala-Asn(Trt)-PAB|cas 1638970-43-0|DC Chemicals

Cas No.:	1638970-43-0
Chemical Name:	(S)-2-((S)-2-((S)-2-(7-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)heptanamido)propanamido)propanamido)-N1-(4-hydroxyphenyl)-N4-tritylsuccinamide
Synonyms:	MC-Ala-Ala-Asn(Trt)-PAB; XQN70430; XQN-70430; XQN 70430;
SMILES:	O=C(C[C@H](NC([C@@H](NC([C@@H](NC(CCCCCCN1C(C=CC1=O)=O)=O)C)=O)C)=O)C(NC2=CC=C(C=C2)O)=O)NC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
Formula:	C₄₆H₅₀N₆O₈
M.Wt:	814.94
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

XQN70430, also known as MC-Ala-Ala-Asn(Trt)-PAB, is a hetero bifunctional cross-linker, useful in antibody drug conjugation (ADC). XQN70430 is a fissionable linker which is specifically activated in a tumor microenvironment. XQN70430 was reported in patent WO 2016026458. This product has no formal name at the moment.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC65699	Mal-propyl-Ala-Ala-Asn-PAB	Mal-propyl-Ala-Ala-Asn(Trt)-PAB is a hetero bifunctional cross-linker, useful in antibody drug conjugation (ADC).
DC80073	Azido-PEG4-EV-Cit-PAB-MMAE	Azido-PEG4-EV-Cit-PAB-MMAE is a precursor of antibody drug conjugate.
DC60106	MC-Ala-Ala-Asn(Trt)-PAB	MC-Ala-Ala-Asn(Trt)-PAB, is a hetero bifunctional cross-linker, useful in antibody drug conjugation (ADC). MC-Ala-Ala-Asn(Trt)-PAB is a fissionable linker which is specifically activated in a tumor microenvironment. XQN70430 was reported in patent WO 2016026458.
DC28412	m-PEG5-CH2COOH	m-PEG5-CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
DC8461	Mc-Val-Cit-PABC-PNP（VCMMAE linker）	Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker.
DC8701	Fmoc-Val-Cit-PAB-PNP	Fmoc-Val-Cit-PAB-PNP is a peptide prodrug linker, is a linker for antibody-drug-conjugation (ADC).

MC-​Ala-​Ala-​Asn(Trt)​-​PAB

MC-Ala-Ala-Asn(Trt)-PAB