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Home > Antibody Drug Conjugates > ADCs Linker/Click Chemistry

Fmoc-Val-Cit-PAB-PNP

  Cat. No.:  DC8701   Featured
Chemical Structure
863971-53-3
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Field of application
Fmoc-Val-Cit-PAB-PNP is a peptide prodrug linker, is a linker for antibody-drug-conjugation (ADC).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 863971-53-3
SMILES: CC(C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35
Formula: C40H42N6O10
M.Wt: 766.8
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Fmoc-Val-Cit-PAB-PNP is a peptide prodrug linker, is a linker for antibody-drug-conjugation (ADC).
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC65699 Mal-propyl-Ala-Ala-Asn-PAB Mal-propyl-Ala-Ala-Asn(Trt)-PAB is a hetero bifunctional cross-linker, useful in antibody drug conjugation (ADC).
DC80073 Azido-PEG4-EV-Cit-PAB-MMAE Azido-PEG4-EV-Cit-PAB-MMAE is a precursor of antibody drug conjugate.
DC60106 MC-​Ala-​Ala-​Asn(Trt)​-​PAB MC-​Ala-​Ala-​Asn(Trt)​-​PAB, is a hetero bifunctional cross-linker, useful in antibody drug conjugation (ADC). MC-​Ala-​Ala-​Asn(Trt)​-​PAB is a fissionable linker which is specifically activated in a tumor microenvironment. XQN70430 was reported in patent WO 2016026458.
DC28412 m-PEG5-CH2COOH m-PEG5-CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
DC8461 Mc-Val-Cit-PABC-PNP（VCMMAE linker） Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker.
DC8701 Fmoc-Val-Cit-PAB-PNP Fmoc-Val-Cit-PAB-PNP is a peptide prodrug linker, is a linker for antibody-drug-conjugation (ADC).
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