DMAT(CK2 Inhibitor)

Cas No.:	749234-11-5
Chemical Name:	4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine
Synonyms:	4,5,6,7-tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine;1H-Benzimidazol-2-amine, 4,5,6,7-tetrabromo-N,N-dimethyl-;DMAT;Casein kinase II Inhibitor;CK2 Inhibitor;2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole;4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzo[d]imidazol-2-amine;CK2 Inhibitor II;ck2inhibitor;CK2 Inhibitor II, DMAT;DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE;Casein Kinase II Inhibitor II, DMAT;InSolution™ Casein Kinase II Inhibitor, DMAT;1zoe;K25;CK2 Inhibitor 2;DMAT(CK2 Inhibitor);C9H7br4N3;GTPL9323
SMILES:	BrC1=C(C(=C(C2=C1N([H])C(=N2)N(C([H])([H])[H])C([H])([H])[H])Br)Br)Br
Formula:	C9H7Br4N3
M.Wt:	476.788
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	DMAT is a potent and specific CK2 inhibitor with an IC50 value of 130 nM.
In Vivo:	DMAT application in vivo reduces tumor growth in a xenotransplant model by interference with tumor cell proliferation. Biochemical parameters and histology following DMAT administration revealed no alterations in liver tissue[4].
In Vitro:	DMAT (1 μM-2.5 μM) DMAT is more efficient in killing antiestrogen resistant cells than parental antiestrogen sensitive MCF-7 cells. DMAT-induced cell death of antiestrogen resistant cells is mediated by caspases. DMAT inhibits CK2 activity but the inhibition is similar in the three cell lines, MCF-7, TAMR-1 and 182R-6[1]. DMAT has effects on H295R cell proliferation at concentrations of 10-4 and 10-5mol/Las compared with the control. DMAT (100 μM) significantly increases apoptosis of H295R cells. DMAT (1 nM-1 μM) significantly decreases aldosterone release into supernatants of 72-h H295R cell cultures as compared with the control[2]. DMAT also inhibits PIM1 by a mechanism which is competitive with respect to ATP, and it is a powerful inhibitor of kinases other than CK2[3].