Furin Inhibitor I|CAS 150113-99-8

Cas No.:	150113-99-8
Chemical Name:	Decanoyl-Arg-Val-Lys-Arg-CMK
SMILES:	O=C([C@@H](NC([C@@H](NC([C@@H](NC(CCCCCCCCC)=O)CCCNC(N)=N)=O)C(C)C)=O)CCCCN)N[C@@H](CCCNC(N)=N)C(CCl)=O
Formula:	C₃₄H₆₆ClN₁₁O₅
M.Wt:	744.4
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Furin inhibitor I is a selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, including furin/SPC1 (Ki = ~1 nM), SPC2/PC2 (Ki = 0.36 nM), SPC3/PC1/PC3 (Ki = 2.0 nM), SPC4/PACE4 (Ki = 3.6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki = 0.12 nM). Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent.In addition, it inhibits furin-dependent pro-MMP-2 activation in mononuclear inflammatory cells.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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