Dexamethasone|CAS 50-02-2|DC Chemicals

Cas No.:	50-02-2
Chemical Name:	Dexamethasone
Synonyms:	Dexamethasone;9-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione;9-alpha-fluoro-16-alpha-methylprednisolone;9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione;4,6-Dichloro-1H-imidazo[4,5-c]pyridine;Dexamethasone (DHAP);Dexamethasone solution;dexamethasone base;(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylp;(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;9a-fluoro-16a-methylprednisolone;Auxiron;Corson;Dexa;Dexone;Dezone;DXM;Dxms;Hl-dex;mk125;NSC 34521;Prednisolone F;Decadron;Dexamethazone;Maxidex;Hexadecadrol;Desametasone;Decaspray;Dexacort;Oradexon;Hexadrol;Dexasone;Visumetazone;Mediamethasone;Desamethasone;Superprednol;Deltafluorene;Turbinaire;Dextelan;Dexameth;Decaderm;Millicorten;Gammacorten;Fortecortin;Dexadeltone;Dekacort;Dectancyl;Decasone;Mymethasone;Dinormon;Dexapolcort;Dexalona;Desameton;Desadrene;Cortisumman;Aphtasolon;Dergramin;Calonat;Corsone;Mexidex;Dexason;Fluormethylprednisolone;Azium;Predn;Dexamethasone, topical;Dexasine;DEXAMETHASONE [USP-RS];CAS-50-02-2;9.alpha.-Fluoro-16.alpha.-methyl-11.beta.,21.beta.-trihydroxy-pregna-1,4-diene-3,20-dione;Anemul mono;GTPL3447;Ocu-trol;MK-125;Decacort;Prednisolone, 9alpha -fluoro-16alpha -methyl-;Naquasone (Veterinary);NCGC00091019-07;C22-H29-F-O5;9.alpha.-Fluoro-11.beta.-17.alpha.- 21-trihydroxy-16.alpha.-methylpregna-1,20-dione;9alpha-fluoro-16alpha-methyl-Prednisolone;Decasone R.p.;Prednisolone, 9.alpha.-fluoro-16.alpha.-methyl-;ECR Brand of Dexamethasone;4-alpha-Fluoro-16-alpha-methyl-11-beta,17,21-trihydroxypregna-1,4-diene-3,20-dione;Dexamethasone, United States Pharmacopeia (USP) Reference Standard;Isopto-Dex;DEXAMETHASONE [EMA EPAR];D00292;Q-200939;AB00918428-09;9alpha-Fluoro-16alpha-methylprednisolone;BETAMETHASONE IMPURITY A [EP IMPURITY];Loverine;HB2521;Decacortin;Dexafluorene;9.alpha.-Fluoro-16.alpha.-methylprednisolone;Pregna-1,4-diene-3,20-dione, 9-fluoro-11alpha -methyl-;1-Dehydro-16-alpha-methyl-9-alpha-fluorohydrocortisone;DEXAMETHASONE COMPONENT OF TOBRADEX;Alba-Dex;Dexamethasone, Pharmaceutical Secondary Standard; Certified Reference Material;TaperDex;[3H]-dexamethasone;Apo-dexamethasone;TOBRADEX ST COMPONENT DEXAMETHASONE;Spersadex;Dexamethasone, British Pharmacopoeia (BP) Assay Standard;Pregna-1,4-dieno-3,20-diona, 9-fluoro-11,17,21-trihidroxi-16-metil-, (11beta, 16alfa)-;DEXAMETHASONE [EP MONOGRAPH];DexaSite;DEXASCHEROSON;SCHEMBL3774;16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone;Decameth;AI3-50934;(11.BETA.,16.ALPHA.)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE;1-Dehydro-16alpha-methyl-0alpha-fluorohydrocortisone;TOBRADEX COMPONENT DEXAMETHASONE;DXM (Steroid);s1322;.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol;Diodex;Methylfluorprednisolone;DEXAMETHASONE (MART.);to_000038;Decadrol;Tresaderm (Veterinary);9-fluoro-1...
SMILES:	F[C@@]12[C@]3(C=CC(C=C3CC[C@@]1([H])[C@]1([H])C[C@@H](C)[C@](O)(C(=O)CO)[C@]1(C[C@@H]2O)C)=O)C
Formula:	C₂₂H₂₉FO₅
M.Wt:	392.46
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Dexamethasone is a glucocorticoid receptor agonist.
In Vivo:	It has previously been reported that treatment with Dexamethasone at a dose of 2×5 mg/kg efficiently inhibits lipopolysaccharide (LPS)-induced inflammation. In our experimental system, treatment with a single dose of Dexamethasone 10 mg/kg (i.p.) significantly decreases recruitment of granulocytes as well as spontaneous production of oxygen radicals compared with animals expose to LPS and injected with solvent alone (saline). The effects are statistically significant when administered both 1 h before and 1 h after inhalation of LPS. The number of granulocytes in BALF decreased to levels comparable to healthy animals (given an aerosol of water)[3]. Rats treated with Dexamethasone consume less food and weighed less than control rats. Treated rats also weigh less than pair-fed animals though their food intake is similar. Five days of Dexamethasone injection result in a significant increase in both the liver mass (+42%) and the liver to body weight ratio (+65%). The wet weight of gastrocnemius muscle decreases 20% after 5 days of treatment, but it remains unaffected relative to body weight (g/100 g body weight), indicating that muscle weight loss paralleled body weight loss[4].
In Vitro:	Dexamethasone regulates several transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, leading to the activation and repression of key genes involved in the inflammatory response[1]. Dexamethasone potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM. Dexamethasone (EC50=36 nM) induces transcription of the β2-receptor is found to correlate with glucocorticoid receptor (GR) DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release. Dexamethasone (IC50=0.5 nM) inhibits a 3×κB (NF-κB, IκBα, and I-κBβ), which is associated with inhibition of GM-CSF release[2].

Cat. No.	Product name	Field of application
DCAPI1025	Dexamethasone	Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs used as an anti-inflammatory and immunosuppressant.