Dipivefrin (hydrochloride)|cas 64019-93-8

Cas No.:	64019-93-8
Chemical Name:	(1)-4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylene dipivalate hydrochloride
Synonyms:	Dipivefrin hydrochloride
SMILES:	O=C(C(C)(C)C)OC1=C(OC(C(C)(C)C)=O)C=C(C(CNC)O)C=C1.Cl
Formula:	C₁₉H₃₀ClNO₅
M.Wt:	387.9
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Dipivefrin is a prodrug of epinephrine that is hydrolyzed by cholinesterase and other esterases in the cornea to epinephrine.It reduces the density of cultured bovine primary trabecular meshwork cells (IC50 = 115 µM).Additionally, it induces an elongated, fibroblast-like morphology and disrupts the actin cytoskeleton in bovine primary trabecular meshwork cells when used at a concentration of 103 µM.In cultured bovine corneal endothelial cells, dipivefrin (28 µM) enhances calcium signaling and induces cytotoxicity.Dipivefrin also suppresses primary human corneal keratinocyte proliferation when used at a concentration of 280 µM.5 Formulations containing dipivefrin have been used alone and in combination with β-adrenergic receptor antagonists for the treatment of glaucoma.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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