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Dorsomorphin dihydrochloride

  Cat. No.:  DC7115   Featured
Chemical Structure
1219168-18-9
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Field of application
Dorsomorphin 2Hcl (Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits ALK2, ALK3, and ALK 6 .
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1219168-18-9
Chemical Name: Dorsomorphin Dihydrochloride
Synonyms: Dorsomorphin Dihydrochloride;Dorsomorphin 2HCl;6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine,dihydrochloride;BML-275;Dorsomorphin dihydrochloride (Compound C, BML-275);6-[4-[2-(1-PIPERIDINYL)ETHOXY]PHENYL]-3-(4-PYRIDINYL)-PYRAZOLO[1,5-A]PYRIMIDINE DIHYDROCHLORIDE;BML-275 2HCl;BML275 dihydrochloride;BML-275 dihydrochloride;Compound C dihydrochloride;FD5027;S7306,BML-275,Compound C
SMILES: [H]Cl.[H]Cl.C12=C(C3=CC=NC=C3)C=NN1C=C(C4=CC=C(OCCN5CCCCC5)C=C4)C=N2
Formula: C24H25N5O.2[HCl]
M.Wt: 472.41008
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Dorsomorphin dihydrochloride (BML-275 dihydrochloride) is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109±16 nM.
In Vivo: Administration of Dorsomorphin over 24 h leads to a 60% increase in total serum iron concentrations. Dorsomorphin treatment is therefore effective in reducing basal levels of hepcidin expression and increasing serum iron concentrations in adult mice[3].
In Vitro: HT1080 cells are treated with 10 μM Dorsomorphin for 2 h under 2DG stress. Immunoblot analysis reveals that phosphorylation levels of the catalytic α subunit of AMPK are increased by exposure of HT1080 cells to 2DG, whereas both basal and 2DG-induced phosphorylation levels are clearly reduced when Dorsomorphin is added. Measurements of cellular kinase activity using an ELISA-based assay system confirmed that Dorsomorphin does reduce the endogenous AMPK activity regardless of cell culture conditions[2].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC7115 Dorsomorphin dihydrochloride Dorsomorphin 2Hcl (Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits ALK2, ALK3, and ALK 6 .
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