Eluxadoline|JNJ-27018966|cas 864825-13-8|DC Chemicals

Cas No.:	864825-13-8
Chemical Name:	Eluxadoline dihydrochloride
Synonyms:	Eluxadoline dihydrochloride;5-[[[(2S)-2-amino-3-(4-carbamoyl-2,6-dimethylphenyl)propanoyl]-[(1S)-1-(5-phenyl-1H-imidazol-2-yl)ethyl]amino]methyl]-2-methoxybenzoic acid,dihydrochloride
SMILES:	Cl.Cl.C[C@H](N(C([C@H](CC1=C(C)C=C(C(=O)N)C=C1C)N)=O)CC1=CC=C(OC)C(C(=O)O)=C1)C1=NC=C(C2=CC=CC=C2)N1
Formula:	C₃₂H₃₇Cl₂N₅O₅
M.Wt:	642.572685956955
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Eluxadoline Dihydrochloride is an orally active mixed μ opioid receptor (μOR) agonist δ opioid receptor (δOR) antagonist. in vitro: Eluxadoline is a locally active, mixed ?-opioid receptor (?OR) agonist and δ-opioid receptor (δOR) antagonist being developed for the treatment of IBS-d (diarrhea-predominant irritable bowel syndrome).Eluxadoline, an orally active mixed μ opioid receptor (μOR) agonist δ opioid receptor (δOR) antagonist developed for the treatment of diarrhea-predominant irritable bowel syndrome, normalizes gastrointestinal (GI) transit and defecation under conditions of novel environment stress or post-inflammatory altered GI function. in vivo: Coadministration of a single 200 mg dose of eluxadoline with cyclosporine, and probenecid increased eluxadoline systemic exposure [AUC(0-inf) ] by 4.4- and 1.4-fold, respectively, whereas peak exposure (Cmax) increased 6.2-fold and 1.3-fold, respectively. Cyclosporine had little effect on renal clearance (CLren) of eluxadoline whereas probenecid reduced CLren by nearly 50%.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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