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Furamidine

  Cat. No.:  DC28266   Featured
Chemical Structure
73819-26-8
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More than 5000 active chemicals with high quality for research!
Field of application
Furamidine (DB75) is abisbenzamidine derivative and an antiparasite agent. Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 µM, 283 µM, and >400 µM, respectively).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 73819-26-8
Chemical Name: Benzenecarboximidamide,4,4'-(2,5-furandiyl)bis-
Synonyms: Benzenecarboximidamide,4,4'-(2,5-furandiyl)bis-;4,4'-(2,5-Furandiyl)bis(benzenecarboximidamide);4,4'-furan-2,5-diyldibenzenecarboximidamide;DB-075;DB-75;Trypanosoma b. Rhodesiense;P. falciparum;Furamidine;NCGC00014688-03;NCIStruc1_001694;4,4'-(Furan-2,5-diyl)dibenzimidamide;DB 75;CCG-37385;2,5-bis(4-amidinophenyl)furan;HY-110137A;SCHEMBL549198;Benzenecarboximidamide, 4,4'-(2,5-furandiyl)bis-;08GH1YF0RA;DB75;2,5-Bis(4-amidinophenyl)-furan;NCGC00097791-01;NCI305831;Furamidine Dihydrochloride;NSC305831;NCGC00014688;NCGC00014688-06;CS-0058706;73819-26-8 (free base);NCI60_002601;NCIStruc2_001468;NCGC00014688-02;NSC-305831;73819-26-8;BRN 1435532;Furandiamidine;DTXSID00224264;5-18-07-00177 (Beilstein Handbook Reference);Benzenecarboximidamide, 4,4'-(2,5-furandiyl)bis-, dihydrochloride;AKOS030254780;BGF;UNII-08GH1YF0RA;55368-40-6;BDBM50388602;DB75;NSC 305831;4-[5-(4-carbamimidoylphenyl)furan-2-yl]benzenecarboximidamide;CHEMBL24057;NCGC00097791-02;4,4'-(2,5-FURANDIYL)BIS [BENZENECARBOXIMIDAMIDE];NSC 305831;4,4'-(2,5-FURANDIYL)BIS (BENZENECARBOXIMIDAMIDE);4,4'-(2,5-FURANDIYL)BIS (BENZENECARBOXIMIDAMIDE);4,4'-(2,5-FURANDIYL)BIS (BENZENECARBOXIMIDAMIDE);4,4'-(2,5-FURANDIYL)BIS (BENZENECARBOXIMIDAMIDE);4,4'-(2,5-FURANDIYL)BIS (BENZENECARBOXIMIDAMIDE);DTXCID00146755;DTXCID00146755;DTXCID00146755;DTXCID00146755;DTXCID00146755;DB-202489;DB-202489;DB-202489;DB-202489;DB-202489;DB-75 compound;DB-75 compound;DB-75 compound;DB-75 compound;DB-75 compound;Furamidine dihydrochloride?;Furamidine dihydrochloride?;Furamidine dihydrochloride?;Furamidine dihydrochloride?;Furamidine dihydrochloride?;WR 199385;WR 199385;WR 199385;WR 199385;WR 199385;4-[5-(4-Carbamimidoylphenyl)-2-furyl ]benzenecarboximidamide;4-[5-(4-Carbamimidoylphenyl)-2-furyl ]benzenecarboximidamide;4-[5-(4-Carbamimidoylphenyl)-2-furyl ]benzenecarboximidamide;4-[5-(4-Carbamimidoylphenyl)-2-furyl ]benzenecarboximidamide;4-[5-(4-Carbamimidoylphenyl)-2-furyl ]benzenecarboximidamide;DB-262847;DB-262847;DB-262847;DB-262847;DB-262847;WR-199385;WR-199385;WR-199385;WR-199385;WR-199385;2,5-BAPF;2,5-BAPF;2,5-BAPF;2,5-BAPF;2,5-BAPF;4,4'-(2,5-Furandiyl)bisbenzenecarboximidamide Dihydrochloride; 2,5-Bis(4-amidinophenyl)furan Dihydrochloride; 2,5-Bis(4-guanylphenyl)furan Dihydrochloride; WR 199385;4,4'-(2,5-Furandiyl)bisbenzenecarboximidamide Dihydrochloride; 2,5-Bis(4-amidinophenyl)furan Dihydrochloride; 2,5-Bis(4-guanylphenyl)furan Dihydrochloride; WR 199385;4,4'-(2,5-Furandiyl)bisbenzenecarboximidamide Dihydrochloride; 2,5-Bis(4-amidinophenyl)furan Dihydrochloride; 2,5-Bis(4-guanylphenyl)furan Dihydrochloride; WR 199385;4,4'-(2,5-Furandiyl)bisbenzenecarboximidamide Dihydrochloride; 2,5-Bis(4-amidinophenyl)furan Dihydrochloride; 2,5-Bis(4-guanylphenyl)furan Dihydrochloride; WR 199385;4,4'-(2,5-Furandiyl)bisbenzenecarboximidamide Dihydrochloride; 2,5-Bis(4-amidinophenyl)furan Dihydrochloride; 2,5-Bis(...
SMILES: C1=CC(=CC=C1C2=CC=C(O2)C3=CC=C(C=C3)C(=N)N)C(=N)N
Formula: C18H16N4O
M.Wt: 304.35
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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DC48830 GSK3494245 GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the β4 and β5 subunits (IC50=0.16 μM for WT L. donovani proteasomes). GSK3494245 moderately inhibits chymotrypsin-like activity of human proteasome (IC50: purified 26S=13 µM; enriched THP-1 extracts IC50=40µM). GSK3494245 exhibits attractive biological and biosafety properties.
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