Cas No.: | 1616392-22-3 |
Chemical Name: | (S)-6-((1-acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide |
Synonyms: | EPZ015938; EPZ 015938; EPZ-015938 |
SMILES: | O=C(C)N1CCC(NC2=NC=NC(C(NC[C@H](O)CN3CCC(C=CC=C4)=C4C3)=O)=C2)CC1 |
Formula: | C24H32N6O3 |
M.Wt: | 452.55 |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM. |
In Vitro: | GSK3326595 (EPZ015938), has entered clinical trials for the treatment of solid tumors and non-Hodgkin’s lymphoma[1]. |