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HS271

  Cat. No.:  DC42322  
Chemical Structure
2410393-15-4
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More than 5000 active chemicals with high quality for research!
Field of application
HS271 is a highly potent, orally active and selective IRAK4, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2410393-15-4
Chemical Name: HS271
SMILES: O=C(NC1=CC2=CN(CCN(C)C)N=C2C=C1C(C)(O)C)C3=NC(C(F)(F)F)=CC=C3
Formula: C21H24F3N5O2
M.Wt: 435.44
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
TITLE DOWNLOAD
MSDS_25929_DC42322_2410393-15-4
COA
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Cat. No. Product name Field of application
DC46171 PROTAC IRAK4 degrader-5 PROTAC IRAK4 degrader-5 is a PROTAC-based IRAK4 degrader extracted from patent US20190192668A1, compound I-171.
DC42505 IRAK-4 protein kinase inhibitor 2 IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders.
DC42322 HS271 HS271 is a highly potent, orally active and selective IRAK4, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties.
DC40577 IRAK inhibitor 4 IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.
DC40037 JH-X-119-01 hydrochloride JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice.
DC28331 IRAK4-IN-4 IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.
DC11185 PF-06426779 PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM.
DC9492 IRAK inhibitor 2 IRAK inhibitor 2 is interleukin-1 receptor associated kinase inhibitor .
DC11497 IRAK4-IN-28 A novel potent, selective IRAK4 inhibitor with IC50 of 51 nM.
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