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IKK-16 HCl

  Cat. No.:  DC7158   Featured
Chemical Structure
1186195-62-9
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More than 5000 active chemicals with high quality for research!
Field of application
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1186195-62-9
Chemical Name: IKK 16
Synonyms: IKK 16;IKK-16 (hydrochloride) NEW;IKK-16 Hydrochloride
SMILES: Cl.C1CCN(C2CCN(C(C3=CC=C(NC4N=CC=C(C5=CC6=CC=CC=C6S5)N=4)C=C3)=O)CC2)C1
Formula: C28H30ClN5Os
M.Wt: 520.088703632355
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: IKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively[1]. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM[2].
References: [1]. Waelchli R, et al. Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorg Med Chem Lett. Bioorg Med Chem Lett. 2006 Jan 1;16(1):108-12. [2]. Hermanson SB, et al. Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation. PLoS One. 2012;7(8):e43580.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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