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Home > Inhibitors & Agonists > NF-κB Pathway > IκB kinase (IKK)

IKK(epsilon)-IN-1 (IKKE-IN-1)

  Cat. No.:  DC7802   Featured
Chemical Structure
1292310-49-6
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More than 5000 active chemicals with high quality for research!
Field of application
IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1292310-49-6
Chemical Name: IKK epsilon-IN-1
Synonyms: IKK epsilon-?IN-?1;Ikk epsilon-in-1;IKKε-IN-1;IKK;A-IN-1;IKKepsilon-IN-1;TBK1/IKKepsilon-IN-2;5-(2-((4-Morpholinophenyl)amino)pyrimidin-4-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile;5-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)-2-(oxan-4-yloxy)benzonitrile;AOB6849;BWABTWGSXHTHCG-UHFFFAOYSA-N;BCP10993;IKK(epsilon)-IN-1 (IKKE-IN-1);B4825;5-[2-[(4-morpholinophenyl)amino]py;TBK1/IKKε-IN-2
SMILES: O1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])OC1C([H])=C([H])C(C2C([H])=C([H])N=C(N=2)N([H])C2C([H])=C([H])C(=C([H])C=2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C=1C#N
Formula: C26H27N5O3
M.Wt: 457.5243
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.
In Vitro: TBK1/IKKε-IN-2 (Cmpound #1) inhibits TBK1 biochemical function in Ulight kinase assay at 5 and 250 μM ATP concentration with IC50s of 0.6 and 2.6 nM, rsespectively. TBK1/IKKε-IN-2 inhibits IKKε biochemical function in Ulight kinase assay at 10 μM ATP with an IC50 of 3.9 nM. The IC50 of TBK1/IKKε-IN-2 in the Panc 02.13 proliferation assay is 5 μM[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC8761 BMS-345541 BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
DC7759 WS6 WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
DC7760 WS3 WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM(induced R7T1 proliferation).
DC8065 LY2409881 trihydrochloride LY2409881 is a novel inhibitor of IκB kinase β (IKK2).
DC8770 IMD-0354 IMD-0354 is a synthetic selective NF-kB inhibitor.
DC7802 IKK(epsilon)-IN-1 (IKKE-IN-1) IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.
DC9485 IKK-16(free base) IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
DC7158 IKK-16 HCl IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
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