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| Cas No.: | 505-44-2 |
| Chemical Name: | Propane,1-isothiocyanato-3-(methylsulfinyl)- |
| Synonyms: | Propane,1-isothiocyanato-3-(methylsulfinyl)-;Iberin;1-ISOTHIOCYANATO-3-(METHYLSULFINYL)PROPANE;1-isothiocyanato-3-methylsulfinylpropane;IBERIN(RG);3-Methylsulfinylpropyl isothiocyanate;3-Methylsulphinylpropylisothiocyanate;C5H9NOS2;METHYLSULFINYLPROPYLISOTHIOCYANATE;sulfpraphane |
| SMILES: | O=S(CCCN=C=S)C |
| Formula: | C5H9NOs2 |
| M.Wt: | 163.26106 |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Iberin, a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. It inhibits cell survival with an IC50 of 2.3 μM in HL60 cell. |
| In Vivo: | Iberin is tested in an in vivo foreign-body infection mouse model, and the results show no significantly difference in bacterial clearance between treated and nontreated miced[4]. Iberin increases tissue levels of the phase II detoxification enzymes quinone reductase and glutathione S-transferase in a variety of rat tissues[5]. |
| In Vitro: | Iberin inhibits the growth of neuroblastoma cells in a dose- and time-dependent manner. The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase in apoptotic cell death in iberin treated cells as compared with control cells. The iberin-induced apoptosis is found to be associated with activation of caspase-9, caspase-3, and PARP[2]. Iberin inhibits growth of human glioblastoma cells in cell proliferation assays, enhances cytotoxicity, and induces apoptosis by activation of caspase-3 and caspase-9[3]. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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