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Imetit dihydrobromide

  Cat. No.:  DC28113   Featured
Chemical Structure
32385-58-3
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Field of application
Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 32385-58-3
Chemical Name: Carbamimidothioic acid,2-(1H-imidazol-5-yl)ethyl ester, hydrobromide (1:2)
Synonyms: Carbamimidothioic acid,2-(1H-imidazol-5-yl)ethyl ester, hydrobromide (1:2);IMETIT DIHYDROBROMIDE;S-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide;S-[2-(4(5)-Imidazolyl)ethyl]isothiourea dihydrobromide;Carbamimidothioic acid, 2-(1H-imidazol-4-yl)ethyl ester dihydrobromide
SMILES: Br.Br.NC(SCCC1=CN=CN1)=N
Formula: C6H12Br2N4S
M.Wt: 332.059277534485
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM)[1][2][3].
Target: H3 Receptor:0.3 nM (Ki) H4 receptor:2.7 nM (Ki)
In Vivo: Imetit dihydrobromide (2.5-10 mg/kg; i.p.) reduces the licking response induced by Apomorphine[4]. Animal Model: Male Sprague-Dawley rats[4] Dosage: 2.5, 5, 10 mg/kg Administration: i.p. (30 min before Apomorphine) Result: Reduced the licking response induced by Apomorphine.
References: [1]. Liu C, et al. Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. [2]. Ling P, et al. Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol. 2004 May;142(1):161-71. [3]. Garbarg M, et al. S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J Pharmacol Exp Ther. 1992 Oct;263(1):304-10. [4]. Farzin D, et al. Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rat. Eur J Pharmacol. 2000 Sep 15;404(1-2):169-74.
MSDS
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LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC28113 Imetit dihydrobromide Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM).
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