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Ciproxifan (maleate)

  Cat. No.:  DC9466   Featured
Chemical Structure
184025-19-2
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More than 5000 active chemicals with high quality for research!
Field of application
Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 184025-19-2
Chemical Name: Cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone;formic acid;prop-2-enoic acid
Synonyms: CIPROXIFAN;(4-(3-(1H-Imidazol-5-yl)propoxy)phenyl)(cyclopropyl)methanone maleate;(Z)-but-2-enedioic acid,cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone;Ciproxifan Maleate;FUB 359 Maleate salt;FUB-359;cyclopropyl{4-[3-(1H-imidazol-5-yl)propoxy]phenyl}methanone (2Z)-but-2-enedioate;FUB 359 maleate;FUB 359 maleate salt, Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt;FUB-359 maleate;Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt;Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxy]phenyl]methanone (2Z)-2-butenedioate;Ciproxifan Moleate;Ciproxifan Maleate (FUB-359);Cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone;formic acid;prop-2-enoic acid
SMILES: OC=O.C=CC(O)=O.N1C=C(N=C1)CCCOC2=CC=C(C=C2)C(=O)C3CC3
Formula: C20H24N2O6
M.Wt: 388.4144
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes
Target: H3 receptor
In Vitro: Ciproxifan behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. This appears to be an orally bioavailable, extremely selective and potent H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.
References: [1]. Motawaj M, Arrang JM. Ciproxifan, a histamine H?-receptor antagonist?/?inverse agonist, modulates methamphetamine-induced sensitization in mice. Eur J Neurosci. 2011 Apr;33(7):1197-204. doi: 10.1111/j.1460-9568.2011.07618.x. [2]. Bardgett ME, Davis NN, Schultheis PJ, Griffith MS. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem. 2011 Jan;95(1):64-72. [3]. Bardgett ME, Points M, Kleier J, Blankenship M, Griffith MS. The H3 antagonist, ciproxifan, alleviates the memory impairment but enhances the motor effects of MK-801 (dizocilpine) in rats. Neuropharmacology. 2010 Nov;59(6):492-502. [4]. Day M, et al . Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test. Biochem Pharmacol. 2007 Apr 15;73(8):1123-34. [5]. Pillot C, Héron A, Schwartz JC, Arrang JM. Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum. Eur J Neurosci. 2003 Jan;17(2):307-14.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
Cat. No. Product name Field of application
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