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Indoximod (NLG-8189)

  Cat. No.:  DC8021   Featured
Chemical Structure
110117-83-4
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Field of application
NLG-8189 is an inhibitor of IDO and INDOL1 (IDO2)
Cas No.: 110117-83-4
Chemical Name: (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid
Synonyms: IndoxiMod;1-METHYL-D-TRYPTOPHAN;1-Methyl-D-tryptophane
SMILES: CN1C=C(C2=CC=CC=C21)C[C@H](C(=O)O)N
Formula: C12H14N2O2
M.Wt: 218.3
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Indoximod (D-1MT, NLG8189) is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor with a Ki of 19 μM.
In Vivo: The D isomer is more efficacious as an anticancer agent in chemo-immunotherapy regimens using cyclophosphamide, paclitaxel, or gemcitabine, when tested in mouse models of transplantable melanoma and transplantable and autochthonous breast cancer. The D isomer of 1-methyl-tryptophan specifically targets the IDO gene because the antitumor effect of d-1-methyl-tryptophan is completely lost in mice with a disruption of the IDO gene (IDO-knockout mice). Oral administration of dl-1-methyl-tryptophan in combination with paclitaxel can elicit regression of autochthonous breast tumors[1].
In Vitro: The IDO inhibitor 1-methyl-tryptophan exists in two stereoisomers with potentially different biological properties. The L isomer is the more potent inhibitor of IDO activity using the purified enzyme and in HeLa cell–based assays. However, the D isomer is significantly more effective in reversing the suppression of T cells created by IDO-expressing dendritic cells. The L isomer of 1-methyl-tryptophan functioned as a competitive inhibitor (Ki=19 μM), whereas the d isomer is much less effective. The DL mixture is intermediate, with a Ki of 35 μM[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC8021 Indoximod (NLG-8189) NLG-8189 is an inhibitor of IDO and INDOL1 (IDO2)
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