Cas No.: | 2375196-30-6 |
Chemical Name: | KB02-COOH |
SMILES: | O=C(O)COC1=CC2=C(N(C(CCl)=O)CCC2)C=C1 |
Formula: | C13H14ClNO4 |
M.Wt: | 283.71 |
Purity: | >98% |
Sotrage: | Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 month |
Description: | KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 and KB02-SLF. |
References: | [1]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746. |