L-189|NHEJ inhibitor|cas 64232-83-3|DC Chemicals

Cas No.:	64232-83-3
Chemical Name:	6-Amino-5-(benzylideneamino)-2-sulfanyl-4-pyrimidinol
Synonyms:	4(1H)-Pyrimidinone,6-amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-;L189;L-189;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone;6-amino-5-(benzylideneamino)-2-sulfanyl-4-pyrimidinol;6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one;(E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one;BCP15116;SBB100144;X3560;B7426;L 189;5-((1E)-2-phenyl-1-azavinyl)-6-amino-2-sulfanylpyrimidin-4-ol
SMILES:	S=C1N([H])C(C(=C(N([H])[H])N1[H])/N=C(\[H])/C1C([H])=C([H])C([H])=C([H])C=1[H])=O
Formula:	C₁₁H₁₀N₄Os
M.Wt:	246.2883
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

L189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM.IC50 value: 5/9/5 μM (for hLigI/III/IV)Target: DNA ligasein vitro: L189 is a competitive inhibitor with respect to nicked DNA. L189 inhibits DNA ligases I, III and IV in DNA joining assays with purified proteins and in cell extract assays of DNA replication, base excision repair and non-homologous end joinging. L189 markedly increases killing of HCT116 colon cancer cells and the other cancer cell lines by ionizing radiation.

References:

[1]. Xi Chen, Shijun Zhong, Xiao Zhu, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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