Lanraplenib monosuccinate
Cat. No.: DC28254
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Chemical Structure
1800046-97-2
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Field of application
Lanraplenib monosuccinate (GS-9876 monosuccinate) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib monosuccinate (GS-9876 monosuccinate) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.
| Cas No.: |
1800046-97-2 |
| Chemical Name: |
Lanraplenib (monosuccinate) |
| Synonyms: |
Butanedioic acid, compd. with 6-(6-amino-2-pyrazinyl)-N-[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]imidazo[1,2-a]pyrazin-8-amine (1:1);Lanraplenib (monosuccinate);6-(6-Aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine succinate;6-(6-aminopyrazin-2-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine;butanedioic acid;Lanraplenib monosuccinate |
| SMILES: |
O1C([H])([H])C([H])(C1([H])[H])N1C([H])([H])C([H])([H])N(C2C([H])=C([H])C(=C([H])C=2[H])N([H])C2C3=NC([H])=C([H])N3C([H])=C(C3=C([H])N=C([H])C(N([H])[H])=N3)N=2)C([H])([H])C1([H])[H].O([H])C(C([H])([H])C([H])([H])C(=O)O[H])=O |
| Formula: |
C27H31N9O5 |
| M.Wt: |
561.5923 |
| Purity: |
98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
MSDS
| TITLE |
DOWNLOAD |
| MSDS_12309_DC28254_1800046-97-2 |
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COA
| LOT NO. |
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