Lipoic acid

  Cat. No.:  DCL-027   Featured
Chemical Structure
62-46-4
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Field of application
Lipoic acid is a selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM. Lipoic acid shows a favorable selectivity profile on Nav, Cav, SK, and IK channels. Lipoic acid causes distinct activation from a concentration of 0.3 and 10 µM Lipoic acid left-shifted the voltage activation curve by 60 mV. Lipoic acid reduces spontaneous phasic contractions in guinea pig urinary bladder strips at 1 uM, while having only a modest effect on contractions evoked by electrical field stimulation (EFS) and no effect on high K+-induced contractions.
Cas No.: 62-46-4
Chemical Name: Lipoic acid
Synonyms: thioctic acid;5-(1,2-dithiolan-3-yl)valeric acid;Thiocitic Acid;1,2-Dithiolane-3-pentanoic acid;1,2-dithiolane-3-valeric acid;6,8-thioctic acid;a-lipoic acid;5-[3-(1,2-dithiolanyl)]pentanoic acid;d-[3-(1,2-dithiacyclopentyl)]pentanoic acid;protogen A;acetate replacing factor;pyruvate oxidation factor;Alpha Lipoic Acid;Lipoic acid;DL-THIOCTIC ACID;R-Alpha-Lipoic Acid;(R)-lipoic acid;R-(+)-alpha-Lipoic acid;(R)-5-(1,2-Dithiolan-3-yl)pentanoic acid;Heparlipon;(+)-alpha-Lipoic acid;Thioctic acid d-form;(R)-alpha-Lipoic acid;(R)-(+)-1,2-Dithiolane-3-pentanoic acid;Tioctic Acid;D-Thioctic acid;R-(+)-Thioctic acid;(R)-(+)-lipoic acid;(R)-1,2-Dithiolane-3-pentanoic acid;(R)-6,8-thioctic acid;lipoate;(R)-1,2-Dithiolane-3-valeric Acid;5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid;(R)-(+)-Lipoate;1,2-Dithiolane-3R-
SMILES: S1[C@@]([H])(C([H])([H])C([H])([H])S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)O[H]
Formula: C8H14O2S2
M.Wt: 206.3256
Purity: >98%, Standard References Grade
Sotrage: 4°C for 1 year, -20°C for more than 2 years
Description: For the detailed information of Lipoic acid, the solubility of Lipoic acid in water, the solubility of Lipoic acid in DMSO, the solubility of Lipoic acid in PBS buffer, the animal experiment(test) (test) of Lipoic acid, the cell expriment (test) of Lipoic acid, the in vivo, in vitro and clinical trial test of Lipoic acid, the EC50, IC50,and Affinity of Lipoic acid,, please contact DC Chemicals.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DCL-027 Lipoic acid Lipoic acid is a selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM. Lipoic acid shows a favorable selectivity profile on Nav, Cav, SK, and IK channels. Lipoic acid causes distinct activation from a concentration of 0.3 and 10 µM Lipoic acid left-shifted the voltage activation curve by 60 mV. Lipoic acid reduces spontaneous phasic contractions in guinea pig urinary bladder strips at 1 uM, while having only a modest effect on contractions evoked by electrical field stimulation (EFS) and no effect on high K+-induced contractions.
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