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Lomeguatrib(PaTrin-2)

  Cat. No.:  DC7188   Featured
Chemical Structure
192441-08-0
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More than 5000 active chemicals with high quality for research!
Field of application
Lomeguatrib (PaTrin-2) is a modified guanine base, which can repress the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) with an IC50 value of 6 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 192441-08-0
Chemical Name: Lomeguatrib
Synonyms: Lomeguatrib;2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine;2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine O6-(4-bromothenyl)guanine;6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine;PaTrin 2;PaTrin-2;O6-(4-bromothenyl)guanine;C521206;Lomeguqtrib;Lomeguaritrib;LoMeguatrib(PaTrin-2);6-((4-Bromo-2-thienyl)methoxy)purin-2-amine;6-[(4-BroMo-2-thienyl)Methoxy]-9H-purin-2-aMine;6-[(4-BroMo-2-thienyl)Methoxy] -1H-purin-2-aMine;Lomeguatrib, >=98%;6-(4-Bromothenyloxy)-7H-purin-2-amine;S79265T71M;6-((4-Bromo-2-thienyl)methoxyl)purin-2-amine;6-((4-bromothiophen-2-yl)methoxy)-7H-purin-2-amine;1H-Purin-2-amine, 6-[(4-bromo-2-thienyl)methoxy]-;Lomeguatrib [INN];Lomeguatrib [INN:BAN];O(6)-(4-bromothenyl)guanine;6-((4-brom
SMILES: BrC1=C([H])SC(=C1[H])C([H])([H])OC1C2=C(N=C(N([H])[H])N=1)N=C([H])N2[H]
Formula: C10H8BrN5Os
M.Wt: 326.1724
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Lomeguatrib is a O6-methylguanine-DNA methyltransferase (MGMT) inhibitor, with IC50s of 9 nM in cell-free assay and ∼6 nM in MCF-7 cells.
In Vivo: Lomeguatrib (20 mg/kg i.p.) completely inactivates MGMT within 2 h, but shows no significant effect on tumor growth in MCF-7 xenografts[2].
In Vitro: Lomeguatrib (Compound 10) is a O6-methylguanine methyltransferase (MGMT) inhibitor, with an IC50 of 9 nM in cell-free assay[1] and ∼6 nM in MCF-7 cells. Lomeguatrib (10 μM) substantially increases the growth inhibitory effects of temozolomide in MCF-7 cells (D60=10 μM with Lomeguatrib vs 400 μM without)[2].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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