Lonidamine|cas 50264-69-2|supplier DC Chemicals

Cas No.:	50264-69-2
Chemical Name:	Lonidamine
Synonyms:	1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid;1-(2,4-Dichlorobenzyl)indazole-3-carboxylic acid;Lonidamine;1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid;1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid;1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid Diclondazolic acid;AF1890;DICA;Diclondazolic acid;Doridamina;Lonidamin;Lonidamina;Lonidaminum;Lonidaminum [INN-Latin];AF 1890;Lonidamina [INN-Spanish];1-(2,4-Dichlorbenzyl)-indazole-3-carboxylic acid;MLS000028822;C15H10Cl2N2O
SMILES:	ClC1C([H])=C(C([H])=C([H])C=1C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C(C(=O)O[H])=N1)Cl
Formula:	C₁₅H₁₀Cl₂N₂O₂
M.Wt:	321.1581
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Lonidamine is an orally administered small molecule hexokinase inactivator.Target: OthersLonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase. Later studies in Ehrlich ascites tumor cells showed that lonidamine inhibits both respiration and glycolysis leading to a decrease in cellular ATP. Clinical trials of lonidamine in combination with other anticancer agents for a variety of cancers has begun. Lonidamine has been used in the treatment of brain tumours in combination with radiotherapy and temozolomide. Results showed that a combination of temozolomide and lonidamine at clinically achievable, low plasma concentrations, could inhibit tumour growth, and lonidamine could reduce the dose of temozolomide required for radiosensitization of brain tumours. From Wikipedia.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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