ML-348(ML348)|LYPLA1 inhibitor

Cas No.:	899713-86-1
Chemical Name:	N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide
Synonyms:	ML 348
SMILES:	N(CC(NC1=CC(C(F)(F)F)=CC=C1Cl)=O)1CCN(C(C2=CC=CO2)=O)CC1
Formula:	C₁₈H₁₇ClF₃N₃O₃
M.Wt:	415.79

Description:

ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM), Exhibits 14-fold selectivity for LYPLA1 over LYPLA2, Also selective over a panel of ~30 other serine hydrolases.target: LYPLA1 [1]IC 50： 210 nM [1]

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC40520	LEI-401	LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. LEI-401 modulates emotional behavior in mice.
DC7591	CAY10650	CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor.
DC7574	FIPI	Potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively).
DC9874	ML-348(ML348)	ML 348(ML348) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).
DC7526	Varespladib	LY315920 (Varespladib) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM,. Phase 3.
DC7397	Darapladib	Darapladib is a selective and orally active inhibitor of Lp-PLA2 (IC50= 270 pM)