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LEI-401

  Cat. No.:  DC40520   Featured
Chemical Structure
2393840-15-6
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More than 5000 active chemicals with high quality for research!
Field of application
LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. LEI-401 modulates emotional behavior in mice.
Cas No.: 2393840-15-6
Chemical Name: Schembl20604119
Synonyms: YW2065;CC1=C(C=NN1C1=C(Br)C=CC=C1)C(=O)NC1=NC2=CC=CC=C2C=C1;1-(2-Bromophenyl)-5-methyl-N-(quinolin-2-yl)-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 1-(2-bromophenyl)-5-methyl-N-2-quinolinyl-;1H-aPyrazole-a?-acarboxamide, 1-a?2-abromophenyl)a?a?-amethyl-aN-a?-aquinolinyl-;Schembl20604119;LEI-401
SMILES: BrC1=C([H])C([H])=C([H])C([H])=C1N1C(C([H])([H])[H])=C(C(N([H])C2C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C3N=2)=O)C([H])=N1
Formula: C20H15BrN4O
M.Wt: 407.2633
Purity: >98%
Sotrage: Powder-20°C3 years4°C2 yearsIn solvent -80°C6 months-20°C1 month
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC40520 LEI-401 LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. LEI-401 modulates emotional behavior in mice.
DC7591 CAY10650 CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor.
DC7574 FIPI Potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively).
DC9874 ML-348(ML348) ML 348(ML348) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).
DC7526 Varespladib LY315920 (Varespladib) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM,. Phase 3.
DC7397 Darapladib Darapladib is a selective and orally active inhibitor of Lp-PLA2 (IC50= 270 pM)
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