MST312

Cas No.:	368449-04-1
Chemical Name:	Benzamide, N,N'-1,3-phenylenebis[2,3-dihydroxy-
Synonyms:	Mst-312;MST-312 (TELOMERASE INHIBITOR IX);N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide;N,N′-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]
SMILES:	C1(NC(=O)C2C=CC=C(O)C=2O)C=CC=C(NC(=O)C2C=CC=C(O)C=2O)C=1
Formula:	C20H16N2O6
M.Wt:	380.350845336914
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM)[1].
Target:	telomeras[1]
In Vitro:	MST-312 (2~8 μM; 0~72 hours; U-266 cells) reduces cellular viability in a dose dependent and time-dependent manner[1]. MST-312 (2~8 μM; 48 hours; U-266 cells) induces cell apoptosis in a dose-dependent manner[1]. MST-312 (2 μM; 48 hours; U-266 cells) up-regulates the pro-apoptotic gene Bax and down-regulates the anti-apoptotic gene Bcl-2 and suppresses the expression of c-Myc and hTERT genes[1]. Cell Viability Assay[1] Cell Line: U-266 cells Concentration: 2~8 μM Incubation Time: 0~72 hours Result: The viability of U-266 cells was substantially decreased in a dose dependent and time-dependent manner, in response to exposure to MST-312. Apoptosis Analysis[1] Cell Line: U-266 cells Concentration: 2~8 μM Incubation Time: 48 hours Result: Induced cell apoptosis in a dose-dependent manner. RT-PCR[1] Cell Line: U-266 cells Concentration: 2 μM Incubation Time: 48 hours Result: Up-regulated the pro-apoptotic gene Bax and down-regulated the anti-apoptotic gene Bcl-2 and suppressed the expression of c-Myc and hTERT genes.
References:	[1]. Ameri Z, et al. Telomerase inhibitor MST-312 induces apoptosis of multiple myeloma cells and down-regulation of anti-apoptotic, proliferative and inflammatory genes. Life Sci. 2019;228:66-71.