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| Cas No.: | 137975-06-5 |
| Chemical Name: | Mozavaptan free base |
| Synonyms: | OPC-31260; OPC 31260; OPC31260; Mozavaptan. |
| SMILES: | O=C(C1=CC=C(NC(C2=C(C)C=CC=C2)=O)C=C1)N3C(C=CC=C4)=C4C(N(C)C)CCC3 |
| Formula: | C27H29N3O2 |
| M.Wt: | 427.548 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Mozavaptan causes a competitive displacement of [3H]-arginine vasopressin (AVP) binding to both V1 and V2 receptors with IC50 values of 1.2 μM and 14 nM, respectively. The Kd of [3H]-AVP is reduced significantly in both rat liver and kidney in the presence of mozavaptan (Kd=1.1 nM in liver, Kd=1.38 nM in kidney).Mozavaptan at doses of 10 to 100 μg/kg, i.v., inhibits the antidiuretic action of exogenously administered arginine vasopressin in water-loaded, alcohol-anaesthetized rats in a dose-dependent manner. Mozavaptan does not exert an antidiuretic activity suggesting that it is not a partial V2 receptor agonist. Mozavaptan dose-dependently increases urine flow and decreases urine osmolality after oral administration at doses of 1 to 30 mg/kg in normal conscious rats. |
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| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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