NSC 146109 (hydrochloride)|cas 59474-01-0|DC Chemicals

Cas No.:	59474-01-0
Synonyms:	NSC 146109 (hydrochloride)；XI-011
SMILES:	NC(SCC1=C2C(C=CC=C2)=C(C)C3=CC=CC=C31)=N.Cl
Formula:	C₁₇H₁₆N₂S^.HCl
M.Wt:	316.8
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Wang H, et al. A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia. 2011 Jul;13(7):611-9.

Description:

NSC 146109 is an activator of the tumor suppressor p53 that increases expression of p53 and the p53 target DR5 in wild-type and p53-knockout HCT116 colon adenocarcinoma cells.It is selective for p53, having no effect on p73 expression in HCT116 cells at a concentration of 2 μM. NSC 146109 activates p53, which induces cell accumulation in the sub-G0/G1 phase and apoptosis in MCF-7 breast cancer cells.It increases p53 expression, decreases expression of the p53 suppressor MDMX, and reduces viability in a panel of breast cancer cell lines when used at a concentration of 0.5 μM. NSC 146109 also reduces growth of AMC-HN9 head and neck carcinoma (HNC) cells in vitro and in vivo when administered alone or in combination with cisplatin in a mouse xenograft model at a dose of 70 mg/kg.

References:

[1]. Wang H, et al. A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia. 2011 Jul;13(7):611-9.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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