Nimodipine
Cat. No.: DC9131
Chemical Structure
66085-59-4
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Field of application
Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.
| Cas No.: |
66085-59-4 |
| SMILES: |
COCCOC(C1=C(C)NC(C)=C(C(OC(C)C)=O)C1C1=CC=CC([N+]([O-])=O)=C1)=O |
| Formula: |
C21H26N2O7 |
| M.Wt: |
418.44 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.Nimodipine is main use is in the prevention of cerebral vasospasm and resultant ischemia, a complication of subarachnoid hemorrhage (a form of cerebral bleed), specifically from ruptured intracranial berry aneurysms irrespective of the patient's post-ictus neurological condition. Its administration begins within 4 days of a subarachnoid hemorrhage and is continued for three weeks. If blood pressure drops by over 5%, dosage is adjusted. There is still controversy regarding the use of intravenous nimodipine on a routine basis. |
MSDS
COA
| LOT NO. |
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| 2018-0101 |
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