| DC9496 |
HG-10-102-01
|
HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2(IC50=23.3 nM) and the G2019S mutant(IC50=3.2 nM)
|
| DC11288 |
PF-06454589
|
PF-06454589 is a potent and selective LRRK2 inhibitor. |
| DC7971 |
PF-06447475
|
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively. |
| DC8237 |
LRRK2-IN-1
|
LRRK2-IN-1 inhibits both wild-type and G2019S mutant LRRK2 kinase activity with IC50 values of 13 nM and 6 nM , respectively with 0.1 mM ATP in the assay. |
| DC11440 |
LRRK2 inhibitor 18
|
LRRK2 inhibitor 18(Compound 18) is a potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 4.1 nM. |
| DC8379 |
JH-II-127
|
JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor. |
| DC7852 |
LRRK2 inhibitor GSK2578215A
|
GSK2578215A is a potent and highly selective LRRK2 inhibitor; exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant. |
| DC7629 |
GNE-9605
|
GNE-9605 is a highly potent and selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor |
| DC7419 |
GNE-7915
|
GNE-7915 is a highly potent, selective, and brain-penetrable LRRK2 small molecule inhibitor with IC50 of 9 nM in cellular LRRK2 assay; > 100 fold selectivity against a panel of 187 kianses(Ki). |
| DC7418 |
DNL201
|
GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM. |
