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Home > Inhibitors & Agonists > Autophagy > LRRK2

PF-06454589

  Cat. No.:  DC11288   Featured
Chemical Structure
1527473-30-8
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More than 5000 active chemicals with high quality for research!
Field of application
PF-06454589 is a potent and selective LRRK2 inhibitor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1527473-30-8
Chemical Name: 4-[5-(1-methylpyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine
Synonyms: PF-06454589 ,PF 06454589 ,PF06454589
SMILES: CN1N=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1
Formula: C14H16N6O
M.Wt: 284.32
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: PF-06454589 is a potent and selective LRRK2 inhibitor.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC9496 HG-10-102-01 HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2(IC50=23.3 nM) and the G2019S mutant(IC50=3.2 nM)
DC11288 PF-06454589 PF-06454589 is a potent and selective LRRK2 inhibitor.
DC7971 PF-06447475 PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.
DC8237 LRRK2-IN-1 LRRK2-IN-1 inhibits both wild-type and G2019S mutant LRRK2 kinase activity with IC50 values of 13 nM and 6 nM , respectively with 0.1 mM ATP in the assay.
DC11440 LRRK2 inhibitor 18 LRRK2 inhibitor 18(Compound 18) is a potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 4.1 nM.
DC8379 JH-II-127 JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor.
DC7852 LRRK2 inhibitor GSK2578215A GSK2578215A is a potent and highly selective LRRK2 inhibitor; exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.
DC7629 GNE-9605 GNE-9605 is a highly potent and selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor
DC7419 GNE-7915 GNE-7915 is a highly potent, selective, and brain-penetrable LRRK2 small molecule inhibitor with IC50 of 9 nM in cellular LRRK2 assay; > 100 fold selectivity against a panel of 187 kianses(Ki).
DC7418 DNL201 GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM.
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