Phentolamine mesilate|cas 65-28-1|DC Chemicals

Cas No.:	65-28-1
SMILES:	CC1C=CC(N(C2C=CC=C(O)C=2)CC2NCCN=2)=CC=1.CS(=O)(O)=O
Formula:	C₁₈H₂₃N₃O₄S
M.Wt:	377.46
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist.Phentolamine Mesylate is a alpha 1- and alpha 2-blocking agent. Phentolamine leads to an increase in FBM by preferentially antagonizing presynaptic alpha 2-adrenoreceptors over postsynaptic alpha 1-adrenoreceptors. This influence of phentolamine on FBM may be secondary to its effect on ECoG. Promotion of LV-ECoG by catecholamines is mediated via an alpha 1-independent mechanism. phentolamine increased catecholamine release by presynaptic alpha 2-blockade, thereby suppressing the autoinhibition of transmitter release. This excess of catecholamines causes a rise of oxygen consumption and vasodilation by beta-adrenergic stimulation. Under beta-blockade, this excess competitively counteracts the postsynaptic vascular alpha-blockade. The combination of pre- and postsynaptic effects invalidates the use of phentolamine in the assessment of alpha-adrenoceptor-mediated vasoconstrictor tone.

MSDS

COA

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2018-0101

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