Sotalol HCl|cas 959-24-0|DC Chemicals

Cas No.:	959-24-0
Chemical Name:	N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide;hydrochloride
Synonyms:	Sotalol Hydrochloride; Sotalol HCL; Betapace; Betapace AF; Sotacor; Sotalol Monohydrochloride; Darob; Knoll Pharmaceutical Brand of Sotalol;
SMILES:	Cl.CC(NCC(C1=CC=C(NS(=O)(C)=O)C=C1)O)C
Formula:	C₁₂H₂₁ClN₂O₃S
M.Wt:	308.82
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Sotalol Hydrochloride is an adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.Sotalol is a non-selective competitive β-adrenergic receptor blocker that also exhibits Class III antiarrhythmic properties by its inhibition of potassium channels. Sotalol is a competitive beta adrenoceptor antagonist devoid of membrane-stabilizing activity and intrinsic sympathomimetic activity that has no preferential actions on beta 1 or beta 2 responses. Sotalol causes concentration-dependent increases in the contractility of isolated ventricular tissue that is not blocked by previous beta or alpha blockade or catecholamine depletion. Sotalol consistently reduces the heart rate to a greater degree than propranolol and causes significantly less cardiac suppression than propranolol at a given heart rate. Sotalol is not only a beta blocker but a class III antiarrhythmic drug. Its possible antifibrillatory activity was therefore investigated in both the ventricles and atria of dog heart in situ, since vulnerability to fibrillation is not the same in both these parts of the myocardium.

MSDS

COA

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2018-0101

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